EVIDENCE THAT MYOCARDIAL PERFUSION IN SURGICAL REVASCULARIZATION IS INFLUENCED BY FUNCTIONAL ANATOMY BUT NOT ANATOMY ALONE

Surgical Anatomy

Surgical Anatomy

Surgical Anatomy

The adrenal glands were first described in 1552 by the Italian anatomist Bartolomeo Eustachi in his Opuscula Anatomica as ‘‘glandulae renis incumbentes’’ (glands lying on the kidney) [1], but their function remained controversial for the next 300 years [2]. The adrenal have a dual origin (Fig. 2.1a, b), i.e. the cortex arises from mesoderm whereas the medulla has a neuroectodermal origin [2]. T...

Early tumor drug pharmacokinetics is influenced by tumor perfusion but not plasma drug exposure.

PURPOSE Pharmacokinetic parameters derived from plasma sampling are used as a surrogate of tumor pharmacokinetics. However, pharmacokinetics-modulating strategies do not always result in increased therapeutic efficacy. Nonsurrogacy of plasma kinetics may be due to tissue-specific factors such as tumor perfusion. EXPERIMENTAL DESIGN To assess the impact of tumor perfusion and plasma drug expos...

Surgical Applied Anatomy